Methylprednisolone administration alters adenine nucleotide hydrolysis in rat blood serum.
Eur J Pharmacol
; 560(2-3): 212-5, 2007 Apr 10.
Article
em En
| MEDLINE
| ID: mdl-17292883
ABSTRACT
The effect of methylprednisolone on the hydrolysis of adenine nucleotides by rat blood serum enzymes was studied. Adult male Wistar rats were submitted to three different treatments with synthetic steroid methylprednisolone one dose of 50 mg/kg, i.p. (acute); or oral doses of 6 mg/kg dissolved in drinking water for 15 (sub-chronic) or 30 (chronic) days. Decreased ADP hydrolysis was observed after acute and sub-chronic treatments. Furthermore, ATP, ADP and AMP hydrolysis decreased after chronic treatment. These alterations may constitute one of the mechanisms that mediate the development of some of the side effects associated with corticosteroid use.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metilprednisolona
/
Nucleotídeos de Adenina
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article