Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.
J Exp Med
; 175(1): 305-8, 1992 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-1730925
ABSTRACT
Peptides from donor major histocompatibility complex (MHC) molecules were examined for their activation of allogeneically primed T cells. After immunization with either allogeneic spleen cells or a skin allograft, primed T cells proliferate in response to peptides derived from polymorphic regions of alpha and beta chains of class II allo-MHC molecules. The results demonstrate that presentation of donor-MHC peptides by host-derived antigen-presenting cells is a common event in vivo. Thus, self-restricted T cell recognition of processed alloantigens may play a critical role in transplantation. An in-depth understanding of this response may result in the development of additional molecular therapies to combat allograft rejection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Transplante de Pele
/
Rejeição de Enxerto
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Complexo Principal de Histocompatibilidade
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article