Synthesis of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by sequential Ugi/[2+2] ene-enone photocycloadditions.
Org Lett
; 9(7): 1299-302, 2007 Mar 29.
Article
em En
| MEDLINE
| ID: mdl-17323962
ABSTRACT
[structure see text]. We report a new methodology for the construction of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by combining the Ugi multicomponent reaction with [2+2] enone-olefin photochemical transformations. The overall sequence is capable of creating up to five stereocenters; however, in most cases, only two diastereomers are observed.
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01-internacional
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MEDLINE
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En
Ano de publicação:
2007
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Article