Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase.
J Med Chem
; 50(8): 1973-7, 2007 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-17348637
ABSTRACT
Cinnamoly compounds 1a-c and 2a-d were designed, synthesized, and in vitro tested as p300 inhibitors. At different degrees, all tested compounds were proven to inactivate p300, particularly, derivative 2c was the most active inhibitor, also showing high specificity for p300 as compared to other histone acetyltransferases. Most notably, 2c showed anti-acetylase activity in mammalian cells. These compounds represent a new class of synthetic inhibitors of p300, characterized by simple chemical structures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Compostos de Benzilideno
/
Cinamatos
/
Proteínas de Ciclo Celular
/
Cicloexanonas
/
Histona Acetiltransferases
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article