Auto-antibody profiles in patients with active pulmonary tuberculosis.
Int J Tuberc Lung Dis
; 11(3): 306-10, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17352097
ABSTRACT
OBJECTIVES:
To determine the prevalence of a wide array of auto-antibodies in patients with tuberculosis (TB) compared with healthy controls. MATERIALS ANDMETHODS:
Forty-seven consecutive patients (age 47 +/- 21 years, 29 males) with recently diagnosed active pulmonary tuberculosis (PTB) and 39 healthy controls were enrolled. Data collected on a questionnaire included clinical features of the disease, duration of symptoms, presence of fever, cough, arthralgia, myalgia, sicca symptoms and others. Serum samples were collected from the patients' before initiating TB treatment, frozen at -20 degrees C and tested for antinuclear antibodies (ANA), anti-ds DNA, anti-Sm, anti-RNP, anti-Ro, anti-La, and anti-cardiolipin (ACA) (IgG and IgM).RESULTS:
Rheumatic symptoms were relatively rare arthralgia (n = 2), myalgias (n = 2), and eye (n = 1) and mouth dryness (n = 4). The TB patients' mean serum levels of anti-ds DNA, anti-Sm, anti-RNP, anti-SSA (anti-Ro), and anti-ACA-IgM were significantly increased compared with controls (P < 0.05 for all). A significantly higher proportion of TB patients had increased pathological levels of anti-ds DNA (32% vs. 2.5%), anti-Sm (38% vs. 0%), anti-RNP (15% vs. 0%), anti-Ro (64% vs. 10%), anti-ACA-IgG (59% vs. 0%) and anti-ACA-IgM (47% vs. 7.7%) (P < 0.05 for all).CONCLUSIONS:
Patients with active TB have significantly increased titres of various auto-antibodies, including highly specific serological markers, such as anti-Sm. RELEVANCE Differential interpretation of serological studies of patients with systemic manifestations should consider the possibility of PTB.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Tuberculose Pulmonar
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article