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Dosage compensation is less effective in birds than in mammals.
Itoh, Yuichiro; Melamed, Esther; Yang, Xia; Kampf, Kathy; Wang, Susanna; Yehya, Nadir; Van Nas, Atila; Replogle, Kirstin; Band, Mark R; Clayton, David F; Schadt, Eric E; Lusis, Aldons J; Arnold, Arthur P.
Afiliação
  • Itoh Y; Department of Physiological Science, University of California, Los Angeles, CA 90095, USA.
  • Melamed E; Department of Physiological Science, University of California, Los Angeles, CA 90095, USA.
  • Yang X; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  • Kampf K; Department of Physiological Science, University of California, Los Angeles, CA 90095, USA.
  • Wang S; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  • Yehya N; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  • Van Nas A; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  • Replogle K; Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA.
  • Band MR; W.M. Keck Center for Comparative and Functional Genomics, University of Illinois, Urbana, IL 61801, USA.
  • Clayton DF; Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA.
  • Schadt EE; Rosetta Inpharmatics, Seattle, WA 98034, USA.
  • Lusis AJ; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  • Arnold AP; Department of Physiological Science, University of California, Los Angeles, CA 90095, USA.
J Biol ; 6(1): 2, 2007.
Article em En | MEDLINE | ID: mdl-17352797
ABSTRACT

BACKGROUND:

In animals with heteromorphic sex chromosomes, dosage compensation of sex-chromosome genes is thought to be critical for species survival. Diverse molecular mechanisms have evolved to effectively balance the expressed dose of X-linked genes between XX and XY animals, and to balance expression of X and autosomal genes. Dosage compensation is not understood in birds, in which females (ZW) and males (ZZ) differ in the number of Z chromosomes.

RESULTS:

Using microarray analysis, we compared the malefemale ratio of expression of sets of Z-linked and autosomal genes in two bird species, zebra finch and chicken, and in two mammalian species, mouse and human. Malefemale ratios of expression were significantly higher for Z genes than for autosomal genes in several finch and chicken tissues. In contrast, in mouse and human the malefemale ratio of expression of X-linked genes is quite similar to that of autosomal genes, indicating effective dosage compensation even in humans, in which a significant percentage of genes escape X-inactivation.

CONCLUSION:

Birds represent an unprecedented case in which genes on one sex chromosome are expressed on average at constitutively higher levels in one sex compared with the other. Sex-chromosome dosage compensation is surprisingly ineffective in birds, suggesting that some genomes can do without effective sex-specific sex-chromosome dosage compensation mechanisms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Mecanismo Genético de Compensação de Dose / Tentilhões Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Galinhas / Mecanismo Genético de Compensação de Dose / Tentilhões Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2007 Tipo de documento: Article