Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study.
Clin Nutr
; 26(3): 314-21, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17353072
ABSTRACT
BACKGROUND & AIMS:
To examine whether probiotics would reduce the occurrence or duration of acute otitis media (AOM), or the nasopharyngeal carriage of otitis pathogens in otitis-prone children.METHODS:
During this double-blind, placebo-controlled, randomised, 24-week intervention, 309 otitis-prone children (10 months-6 years) consumed either one probiotic capsule (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve 99 and Propionibacterium freudenreichii JS) (n=155) or placebo (n=154) daily. Clinical examinations were carried out and nasopharyngeal samples taken three times. Parents recorded the symptoms of upper respiratory infection (URI) in a diary.RESULTS:
Probiotic treatment did not reduce the occurrence (probiotic vs. placebo 72% vs. 65%, OR=1.48, 95% CI 0.87-2.52, p=n.s.) or the recurrence ( three) of AOM episodes (18% vs. 17%, OR=1.04, 95% CI 0.55-1.96, p=n.s.). The median duration of AOM episodes was 5.6 (IQR 3.5-9.4) vs. 6.0 (IQR 4.0-10.5) days, respectively (p= n.s.). There was a tendency showing a reduction in the occurrence of recurrent (4 to 6) respiratory infections in the probiotic group (OR for 4 URIs 0.56, 95%CI 0.31-0.99, p=0.046; OR for 6 URIs 0.59, 95% CI 0.34 to 1.03, p=n.s.). Probiotics did not affect the carriage of Streptococcus pneumoniae or Haemophilus influenzae, but increased the prevalence of Moraxella catarrhalis (OR=1.79, 95% CI 1.06-3.00, p=0.028).CONCLUSIONS:
Probiotics did not prevent the occurrence of AOM or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. A tendency showing a reduction in recurrent respiratory infections must be confirmed in further studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otite Média
/
Nasofaringe
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Moraxella catarrhalis
/
Probióticos
Tipo de estudo:
Clinical_trials
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Incidence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article