[Expression and clinic pathological significance of survivin mRNA and protein in salivary gland tumors].

ABSTRACT

PURPOSE: The study is aimed to determine the expression of survivin mRNA in salivary gland tumors and its significance in the development and progress of salivary gland tumors. METHODS: The expression of survivin mRNA both in benign and malignant salivary gland tumor tissues and in peripheral tissues was identified by in situ hybridizations assay with the prepared tissue chips. The data were analyzed by Chi-square test and rank sum test using SPSS10.0 software package. RESULTS: The difference in the expression of survivin mRNA was significant between benign and malignant salivary gland tumors (P<0.05). But not significant between the gland tissues around the tumors and malignant tumors (P>0.05). The difference in the expression of survivin mRNA in malignant salivary gland tumor was significant in the pathological grade, lymph node status and relapse of the tumor (P<0.05), but not significant in gender, age of the patients and size of the tumors (P>0.05). CONCLUSIONS: The expression of survivin mRNA is associated with clinic pathological characteristics of the malignant salivary gland tumors. Survivin mRNA may play a crucial role in earlier diagnosis and prognosis of the malignant salivary gland tumors.