Effects of gentian violet on refractory discharging ears infected with methicillin-resistant Staphylococcus aureus.
J Otolaryngol
; 35(6): 384-6, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17380832
ABSTRACT
OBJECTIVE:
To test the efficacy of topical treatment with gentian violet on methicillin-resistant Staphylococcus aureus (MRSA). STUDYDESIGN:
Retrospective study.SETTING:
Territorial referral centre. PATIENTS Patients with discharging ears infected with MRSA alone or MRSA and Pseudomonas aeruginosa (PA). INTERVENTION One percent gentian violet was applied. MAINOUTCOME:
Remission of discharge.RESULTS:
Remission was obtained in 44 of 46 ears infected with MRSA, whereas remission was obtained in only 3 of 6 ears infected with MRSA and PA. The minimum inhibitory concentrations (MICs) of gentian violet for MRSA strains sensitive to topical application of gentian violet and strains resistant to this treatment were 0.03 microg/mL and 0.5%, respectively. The MIC for PA resistant to topical gentian violet treatment was higher than 32 microg/mL.CONCLUSIONS:
Topical application of gentian violet is a useful option for the treatment of refractory discharging ears infected with MRSA. However, great care must be taken if there is any chance of the gentian violet reaching the middle ear.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Staphylococcus aureus
/
Resistência a Meticilina
/
Otopatias
/
Violeta Genciana
/
Anti-Infecciosos Locais
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article