Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.

Brown, Matthew F; Bahnck, Kevin B; Blumberg, Laura C; Brissette, William H; Burrell, Sara A; Driscoll, James P; Fedeles, Flavia; Fisher, Michael B; Foti, Robert S; Gladue, Ronald P; Guzman-Martinez, Aikomari; Hayward, Matthew M; Lira, Paul D; Lillie, Brett M; Lu, Yi; Lundquist, Greg D; McElroy, Eric B; McGlynn, Molly A; Paradis, Timothy J; Poss, Christopher S; Roache, James H; Shavnya, Andrei; Shepard, Richard M; Trevena, Kristen A; Tylaska, Laurie A

Brown, Matthew F; Bahnck, Kevin B; Blumberg, Laura C; Brissette, William H; Burrell, Sara A; Driscoll, James P; Fedeles, Flavia; Fisher, Michael B; Foti, Robert S; Gladue, Ronald P; Guzman-Martinez, Aikomari; Hayward, Matthew M; Lira, Paul D; Lillie, Brett M; Lu, Yi; Lundquist, Greg D; McElroy, Eric B; McGlynn, Molly A; Paradis, Timothy J; Poss, Christopher S; Roache, James H; Shavnya, Andrei; Shepard, Richard M; Trevena, Kristen A; Tylaska, Laurie A.

Afiliação

Brown MF; Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. matthew.f.brown@pfizer.com

Bioorg Med Chem Lett ; 17(11): 3109-12, 2007 Jun 01.

Article em En | MEDLINE | ID: mdl-17383873

Assuntos

Piperazinas/química; Piperazinas/metabolismo; Receptores de Quimiocinas/antagonistas & inibidores; Animais; Cães; Haplorrinos; Humanos; Microssomos Hepáticos/metabolismo; Piperazinas/síntese química; Ratos; Receptores CCR1

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Receptores de Quimiocinas Limite: Animals / Humans Idioma: En Ano de publicação: 2007 Tipo de documento: Article

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