Evaluation of immunoassay-based MMP-8 detection in gingival crevicular fluid on a point-of-care platform.
Ann N Y Acad Sci
; 1098: 490-2, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17435156
ABSTRACT
A novel immunology-based point-of-care test has been designed to assess the activated form of matrix metalloproteinase-8 (aMMP-8) for diagnosis and monitoring of periodontal diseases. The test has been automated using an analyzer, which quantitatively measures aMMP-8 in 18 min in gingival crevicular fluid (GCF). Fluid samples were collected from healthy, gingivitis-, and periodontitis-affected teeth. The test results from the analyzer were compared with quantitative aMMP-8 immunofluorometric assay (IFMA) and in-house enzyme-linked immunosorbent assay (ELISA) as well as with the periodontal state. Preliminary results of analyzer measurements of these 34 clinical samples showed a good agreement with the results from IFMA and in-house ELISA and with the clinical picture.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Líquido do Sulco Gengival
/
Sistemas Automatizados de Assistência Junto ao Leito
/
Metaloproteinase 8 da Matriz
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article