Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii.
Antimicrob Agents Chemother
; 51(7): 2324-8, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17438042
ABSTRACT
The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene bla(OXA-58) but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the bla(OXA-58) gene showed genetic variability, with the presence in several isolates of multiple copies of the bla(OXA-58) gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbapenêmicos
/
Dosagem de Genes
/
Resistência beta-Lactâmica
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Acinetobacter baumannii
/
Genes Bacterianos
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article