Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts.
J Org Chem
; 72(10): 3969-71, 2007 May 11.
Article
em En
| MEDLINE
| ID: mdl-17444687
ABSTRACT
A facile and general protocol for the preparation of isothiocyanates from alkyl and aryl amines is reported. This method relies on a tosyl chloride mediated decomposition of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide and triethylamine. Utilizing this protocol, we have prepared 19-alkyl- and arylisothiocyanates in moderate to excellent yield.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiocarbamatos
/
Compostos de Tosil
/
Isotiocianatos
Tipo de estudo:
Guideline
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article