Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition.
Nat Neurosci
; 10(6): 679-81, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17468749
ABSTRACT
Loss of visual acuity caused by abnormal visual experience during development (amblyopia) is an untreatable pathology in adults. We report that environmental enrichment in adult amblyopic rats restored normal visual acuity and ocular dominance. These effects were due to reduced GABAergic inhibition in the visual cortex, accompanied by increased expression of BDNF and reduced density of extracellular-matrix perineuronal nets, and were prevented by enhancement of inhibition through benzodiazepine cortical infusion.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Visual
/
Acuidade Visual
/
Ambliopia
/
Recuperação de Função Fisiológica
/
Meio Ambiente
/
Inibição Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article