Supramolecular medicinal chemistry: mixed-ligand coordination complexes.
Mol Pharm
; 4(3): 373-85, 2007.
Article
em En
| MEDLINE
| ID: mdl-17497887
ABSTRACT
We report on the supramolecular synthesis and characterization of examples from three series of mixed-ligand coordination complexes composed of copper(II), a drug, and an ancillary ligand (AL). Particularly, we demonstrate how the judicious choice of an ancillary ligand affords a large degree of control over the relative lipophilicity/hydrophilicity of the complex in relation to the uncomplexed drug molecule. Furthermore, we demonstrate several important factors to consider in the design of such complexes such as the additive-constitutive nature of the partition coefficient of the ancillary ligand and the relative size of the two types of ligands.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article