Gentamicin susceptibility in Escherichia coli related to the genetic background: problems with breakpoints.
Clin Microbiol Infect
; 13(8): 830-2, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17501975
ABSTRACT
In total, 120 Escherichia coli isolates positive for one of the gentamicin resistance (GEN(R)) genes aac(3)-II, aac(3)-IV or ant(2'')-I were tested for gentamicin susceptibility by the agar dilution method. Isolates positive for aac(3)-IV or ant(2'')-I had an MIC distribution of 8-64 mg/L, whereas isolates positive for aac(3)-II had MICs of 32 to >512 mg/L, suggesting a relationship between the distribution of MICs and the specific GEN(R) mechanism. The MIC distribution, regardless of the GEN(R) mechanism, was 8 - >512 mg/L, which supports the clinical breakpoint of MIC >4 mg/L suggested by EUCAST and questions the breakpoint recommended by the CLSI (> or =16 mg/L).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gentamicinas
/
Farmacorresistência Bacteriana
/
Escherichia coli
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article