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[Distigmine bromide improves chronic intestinal pseudo-obstruction in a case of MELAS].
Nakae, Yoshiharu; Kishida, Hitaru; Hakii, Yasuhito; Koyano, Shigeru; Suzuki, Yume; Kuroiwa, Yoshiyuki.
Afiliação
  • Nakae Y; Department of Neurology, Yokohama City University, School of Medicine.
Rinsho Shinkeigaku ; 47(4): 177-9, 2007 Apr.
Article em Ja | MEDLINE | ID: mdl-17511291
A 34-year-old man with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) showed chronic intestinal pseudo-obstruction (CIPO), which was improved by the administration of distigmine bromide. He exhibited generalized tonic clonic seizures at the age of 21, and mitochondrial DNA analysis showed the MELAS mutation. At the age of 34, he became akinetic mutism after nonconvulsive status epilepticus and needed enteral nutrition through a nasogasrtic tube. However, he developed abdominal distention and vomiting, and was diagnosed as CIPO, therefore tube feeding was stopped. Although the administration of domperidone, mosapride citrate, butyric acid bacteria, sodium picosulfate, prostaglandin F2 alpha, pantothenic acid, dioctyl sodium sulfosuccinate, and so on, was ineffective, the administration of distigmine bromide improved his bowel motion disturbance and abnormal distention. The present case is the first MELAS patient with CIPO to be ameliorated by distigmine bromide, which might work acetylcholine receptor on the interstitial cells of Cajal.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Piridínio / Pseudo-Obstrução Intestinal / Síndrome MELAS Limite: Adult / Humans / Male Idioma: Ja Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Piridínio / Pseudo-Obstrução Intestinal / Síndrome MELAS Limite: Adult / Humans / Male Idioma: Ja Ano de publicação: 2007 Tipo de documento: Article