Triazabicyclodecene: an effective isotope exchange catalyst in CDCl(3).

Sabot, Cyrille; Kumar, Kanduluru Ananda; Antheaume, Cyril; Mioskowski, Charles

Sabot, Cyrille; Kumar, Kanduluru Ananda; Antheaume, Cyril; Mioskowski, Charles.

Afiliação

Sabot C; Laboratoire de Synthèse Bio-Organique, UMR 7175/LC1-CNRS, Université Louis Pasteur de Strasbourg, B.P. 60024, 67401 Illkirch cedex, France.

J Org Chem ; 72(13): 5001-4, 2007 Jun 22.

Article em En | MEDLINE | ID: mdl-17530896

ABSTRACT

ABSTRACT

We describe the first effective H/D exchange reaction with acidic substrates in CDCl(3) at room temperature. The particularly mild reaction conditions involved (solvent, base, and temperature) allow the chemoselective deuteration of ketones over esters. An NMR study was conducted with the aim of rationalizing the results obtained in the presence of TBD as catalyst.

Assuntos

Compostos Aza/química; Compostos Heterocíclicos com 2 Anéis/química; Hidrocarbonetos Clorados/química; Catálise; Deutério; Concentração de Íons de Hidrogênio; Cetonas/química; Estrutura Molecular

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Aza / Compostos Heterocíclicos com 2 Anéis / Hidrocarbonetos Clorados Idioma: En Ano de publicação: 2007 Tipo de documento: Article

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