Triazabicyclodecene: an effective isotope exchange catalyst in CDCl(3).
J Org Chem
; 72(13): 5001-4, 2007 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-17530896
ABSTRACT
We describe the first effective H/D exchange reaction with acidic substrates in CDCl(3) at room temperature. The particularly mild reaction conditions involved (solvent, base, and temperature) allow the chemoselective deuteration of ketones over esters. An NMR study was conducted with the aim of rationalizing the results obtained in the presence of TBD as catalyst.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Aza
/
Compostos Heterocíclicos com 2 Anéis
/
Hidrocarbonetos Clorados
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article