Pro-inflammatory cytokines IL6, TNF-alpha, IL1beta, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis.
J Infect
; 55(3): 220-5, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17586049
ABSTRACT
OBJECTIVE:
To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE). PATIENTS ANDMETHODS:
Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers interleukin-6 (IL6), tumour necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL1beta), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).RESULTS:
Serum levels of IL6, IL1beta and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-alpha and LBP were not elevated.CONCLUSION:
Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Calcitonina
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Endocardite
/
Interleucina-1beta
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article