Tendon rupture associated with simvastatin/ezetimibe therapy.
Am J Cardiol
; 100(1): 152-3, 2007 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-17599460
ABSTRACT
A case of spontaneous biceps tendon rupture in a physician during therapy with the combination of simvastatin and ezetimibe (Vytorin) is reported. Rechallenge produced tendinopathy in the contralateral biceps tendon that abated with drug discontinuation. Tendon rupture generally occurs in injured tendons. Physiological repair of an injured tendon requires degradation and remodeling of the extracellular matrix through matrix metalloproteinases (MMPs). Statins are known to inhibit MMPs. It was hypothesized that statins may increase the risk of tendon rupture by altering MMP activity. In conclusion, statins may increase the risk of tendon rupture by altering MMP activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azetidinas
/
Traumatismos dos Tendões
/
Sinvastatina
/
Anticolesterolemiantes
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article