Effect of acute paracetamol overdose on changes in serum and urine electrolytes.
Br J Clin Pharmacol
; 64(6): 824-32, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17610529
ABSTRACT
AIMS:
To investigate the effects of acute paracetamol overdose on renal function, serum and urine electrolyte excretion in man.METHODS:
Two studies were performed in patients admitted with paracetamol overdose a retrospective study examining changes in serum electrolytes, and a prospective study evaluating changes in serum and urine electrolytes. A control group with SSRI overdose was included in the prospective study.RESULTS:
There was a significant dose-dependent relationship between admission (4 h) paracetamol concentration and fall in serum potassium in the retrospective study (P < 0.01) and a significant positive relationship between serum paracetamol at 4 h and fractional excretion of potassium at 12 h postingestion (P < 0.01) in the prospective study. No changes were seen in the control group. No cases developed renal failure.CONCLUSIONS:
Paracetamol overdose is associated with dose-related hypokalaemia, and kaliuresis of short duration (<24 h), suggesting a specific renal effect of paracetamol in overdose perhaps via cyclo-oxygenase inhibition. This effect seems distinct from any nephrotoxic effect of paracetamol.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eletrólitos
/
Acetaminofen
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article