Incorporation of a designed ruthenium nitrosyl in PolyHEMA hydrogel and light-activated delivery of NO to myoglobin.
Inorg Chem
; 46(16): 6601-6, 2007 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-17616126
ABSTRACT
A ruthenium nitrosyl with 4-vinylpyridine (4-vpy) as one ligand, namely, [Ru(Me2bpb)(NO)(4-vpy)](BF4) (1), has been synthesized and structurally characterized. This diamagnetic {Ru-NO}6 nitrosyl is photoactive and readily releases NO upon exposure to low-intensity (5-10 mW) UV light (quantum yield at 300 nm = 0.18). Radical-induced copolymerization of 2-hydroxyethyl methacrylate (HEMA) and ethyleneglycol dimethacrylate (EGDMA) in the presence of 1 has afforded a 1-pHEMA, a transparent hydrogel in which 1 is covalently attached to the polymer backbone. Exposure of 1-pHEMA to UV light (5-10 mW) results in rapid release of NO (detected by NO electrode) that can be delivered to biological targets such as myoglobin. The photoactivity of 1-pHEMA is strictly dependent on exposure to UV light.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poli-Hidroxietil Metacrilato
/
Rutênio
/
Nitrogênio
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article