Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.
Eur J Med Chem
; 43(3): 662-7, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-17624635
ABSTRACT
A series of deoxybenzoin derivatives from genistein were synthesized and their structures were elucidated by (1)H NMR, mass spectral data and micro analyses. The structures of 2, 7 and 10 were determined by single-crystal X-ray analysis. These obtained compounds were evaluated for their assayed antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Most compounds have displayed comparable antibacterial activity against bacterial. On the basis of the biological results, structure-activity relationships are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzoína
/
Genisteína
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article