Novel clusters of highly expressed genes accompany genomic amplification in breast cancers.
FEBS Lett
; 581(21): 3909-14, 2007 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-17662721
ABSTRACT
Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Regulação Neoplásica da Expressão Gênica
/
Família Multigênica
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Cromossomos Humanos
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Proteínas de Neoplasias
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article