DNA damage-site recognition by lysine conjugates.
Proc Natl Acad Sci U S A
; 104(32): 13016-21, 2007 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-17664419
ABSTRACT
Simple lysine conjugates are capable of selective DNA damage at sites approximating a variety of naturally occurring DNA-damage patterns. This process transforms single-strand DNA cleavage into double-strand cleavage with a potential impact on gene and cancer therapy or on the design of DNA constructs that require disassembly at a specific location. This study constitutes an example of DNA damage site recognition by molecules that are two orders of magnitude smaller than DNA-processing enzymes and presents a strategy for site-selective cleavage of single-strand nucleotides, which is based on their annealing with two shorter counterstrands designed to recreate the above duplex damage site.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Lisina
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article