Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability.
J Neurol Sci
; 263(1-2): 15-9, 2007 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-17673234
ABSTRACT
BACKGROUND:
Fatigue is a major problem in multiple sclerosis (MS), and its association with MRI features is debated.OBJECTIVE:
To study the correlation between fatigue and lesion load, white matter (WM), and grey matter (GM), in MS patients independent of disability.METHODS:
We studied 222 relapsing remitting MS patients with low disability (scoresCONCLUSION:
These results suggest that among MS patients with low disability those with high-fatigue show higher WM and GM atrophy and higher lesion load, and that female sex and higher levels of education may play a protective role towards fatigue. Furthermore, they suggest that in MS, independent of disability, WM and GM atrophy is a risk factor to have fatigue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Estatística como Assunto
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Fadiga
/
Esclerose Múltipla
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article