Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.

Bhattacharya, Anindya; Scott, Brian P; Nasser, Nadia; Ao, Hong; Maher, Michael P; Dubin, Adrienne E; Swanson, Devin M; Shankley, Nigel P; Wickenden, Alan D; Chaplan, Sandra R

Bhattacharya, Anindya; Scott, Brian P; Nasser, Nadia; Ao, Hong; Maher, Michael P; Dubin, Adrienne E; Swanson, Devin M; Shankley, Nigel P; Wickenden, Alan D; Chaplan, Sandra R.

Afiliação

Bhattacharya A; Department of Pain and Related Disorders, Johnson & Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA. abhatta2@prdus.jnj.com

J Pharmacol Exp Ther ; 323(2): 665-74, 2007 Nov.

Article em En | MEDLINE | ID: mdl-17690251

Assuntos

Aminopiridinas/farmacologia; Antitussígenos/farmacologia; Piperazinas/farmacologia; Canais de Cátion TRPV/antagonistas & inibidores; Aminopiridinas/sangue; Animais; Células CHO; Tosse/tratamento farmacológico; Cricetinae; Cricetulus; Relação Dose-Resposta a Droga; Feminino; Cobaias; Masculino; Piperazinas/sangue

Buscar no Google

Imprimir

XML

PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antitussígenos / Piperazinas / Canais de Cátion TRPV / Aminopiridinas Limite: Animals Idioma: En Ano de publicação: 2007 Tipo de documento: Article

Buscar no Google

Imprimir

XML

PubMed Links