Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases.
FEBS Lett
; 581(22): 4260-4, 2007 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-17707374
ABSTRACT
The physiological significance of the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2, members of the ovalbumin serpin family, remains unresolved. In this study, we examined whether SCCA1 or SCCA2 inhibits protozoa- or helminth-derived cysteine proteases. SCCA1, but not SCCA2, potently inhibited the cysteine protease activities of CPB2.8 from Leishmania mexicana, cruzain from Trypanosoma cruzi, rhodesain from Trypanosoma brucei rhodesience, and cathepsin L2 from Fasciola hepatica. The inhibitory activities of SCCA1 were due to its resistance to cleavage by the cysteine proteases. The findings indicate that induction of cysteine protease inhibitors might be a novel defense mechanism against parasite development.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parasitos
/
Cisteína Endopeptidases
/
Inibidores de Cisteína Proteinase
/
Serpinas
/
Antígenos de Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article