Myoglobinuria in boys with Duchenne muscular dystrophy on corticosteroid therapy.
Neuromuscul Disord
; 18(1): 71-3, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-17719224
ABSTRACT
Myoglobinuria is a recognised complication of Duchenne muscular dystrophy (DMD), but has only once been reported in ambulant boys on corticosteroid therapy [Dubowitz V, Kinali M, Main M, Mercuri E, Muntoni F. Remission of clinical signs in early Duchenne muscular dystrophy on intermittent low-dosage prednisolone therapy. Eur J Paediatr Neurol 2002;6(3)153-9.]. We present three prednisolone-treated boys with myoglobinuria and in two cases this was recurrent. All three showed improved motor performance in response to the introduction of corticosteroids. The greater activity of steroid-treated individuals may place their dystrophin-deficient muscles under greater mechanical stress, predisposing to further muscle fibre damage and consequent myoglobinuria. Families and physicians need to have an increased awareness of this possibility and of the appropriate management of myoglobinuria.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Corticosteroides
/
Músculo Esquelético
/
Distrofia Muscular de Duchenne
/
Terapia por Exercício
/
Mioglobinúria
Limite:
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article