Bioassay-guided isolation of kaempferol-3-O-beta-D-galactoside with anti-inflammatory and antinociceptive activity from the aerial part of Calluna vulgaris L.
J Ethnopharmacol
; 114(1): 32-7, 2007 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-17765419
Calluna vulgaris L. (Ericaceae) is used for the treatment of various inflammatory ailments in traditional medicines. In order to evaluate this ethnobotanical information, its anti-inflammatory and antinociceptive activities were studied using in vivo experimental models in mice. The ethanolic extract of the plant was first fractionated into five extracts; namely, n-hexane, chloroform, ethyl acetate (EtOAc), n-butanol, and water fractions. Among them, the EtOAc Fr. was found to be the most effective and was further subjected to bioassay-guided fractionation and isolation procedures. After successive column chromatography applications, on Sephadex LH-20 and silica gel, a component, which is responsible for the above-mentioned activities of this species of Turkish origin, was isolated and its structure was elucidated as kaempferol-3-O-beta-D-galactoside, a common flavonol derivative by means of spectral techniques.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calluna
/
Quempferóis
/
Analgésicos
/
Anti-Inflamatórios
/
Monossacarídeos
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article