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Bioassay-guided isolation of kaempferol-3-O-beta-D-galactoside with anti-inflammatory and antinociceptive activity from the aerial part of Calluna vulgaris L.
Orhan, I; Küpeli, E; Terzioglu, S; Yesilada, E.
Afiliação
  • Orhan I; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
J Ethnopharmacol ; 114(1): 32-7, 2007 Oct 08.
Article em En | MEDLINE | ID: mdl-17765419
Calluna vulgaris L. (Ericaceae) is used for the treatment of various inflammatory ailments in traditional medicines. In order to evaluate this ethnobotanical information, its anti-inflammatory and antinociceptive activities were studied using in vivo experimental models in mice. The ethanolic extract of the plant was first fractionated into five extracts; namely, n-hexane, chloroform, ethyl acetate (EtOAc), n-butanol, and water fractions. Among them, the EtOAc Fr. was found to be the most effective and was further subjected to bioassay-guided fractionation and isolation procedures. After successive column chromatography applications, on Sephadex LH-20 and silica gel, a component, which is responsible for the above-mentioned activities of this species of Turkish origin, was isolated and its structure was elucidated as kaempferol-3-O-beta-D-galactoside, a common flavonol derivative by means of spectral techniques.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calluna / Quempferóis / Analgésicos / Anti-Inflamatórios / Monossacarídeos Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calluna / Quempferóis / Analgésicos / Anti-Inflamatórios / Monossacarídeos Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2007 Tipo de documento: Article