Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia.
J Virol
; 81(22): 12709-14, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17855523
ABSTRACT
An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections. Immunohistochemical analysis confirmed the presence of APMV-1 antigen in sloughed alveolar cells in lung tissue from autopsy. Sequence from the human isolate showed that it was most closely related to virulent pigeon strains of APMV-1. This is the most completely documented case of a systemic human infection caused by APMV-1 and is the first report of an association between this virus and a fatal disease in a human.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Vírus da Doença de Newcastle
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Doença de Newcastle
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article