SIRT1 transgenic mice show phenotypes resembling calorie restriction.
Aging Cell
; 6(6): 759-67, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17877786
ABSTRACT
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sirtuínas
/
Restrição Calórica
/
Longevidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article