Tandem conjugate addition-elimination for the diastereoselective synthesis of 4E-alkenyl syn-1,3-diols.
Org Lett
; 9(21): 4147-50, 2007 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-17880094
ABSTRACT
We have developed a tandem conjugate addition-elimination sequence for the diastereoselective synthesis of protected allylic syn-1,3-diols, starting from vinyl sulfones. The sulfonyl group was then reduced with sodium amalgam to furnish the E-olefin as the major isomer. This method was applied to the synthesis of a trisubstituted alkene modeling the C21-C25 fragment of Dolabelide C.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diterpenos
/
Álcoois
/
Alcenos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article