Preliminary X-ray crystallographic studies of a Lys49-phospholipase A2 homologue from Bothrops pirajai venom complexed with p-bromo-phenacyl bromide and alpha-tocopherol inhibitors.
Protein Pept Lett
; 14(7): 698-701, 2007.
Article
em En
| MEDLINE
| ID: mdl-17897096
ABSTRACT
PrTX-I, a non-catalytic and myotoxic Lys49-PLA(2) from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), alpha tocopherol and alpha tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 A resolution. All complexes crystals are isomorphous and belong to the space group P2(1) whereas native PrTX-I crystals belong to the P3(1)21.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipases A
/
Brometos
/
Venenos de Crotalídeos
/
Alfa-Tocoferol
/
Inibidores Enzimáticos
/
Lisina
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article