[JAK3 mRNA level in graft versus host disease patients: a preliminary study].
Zhonghua Yi Xue Za Zhi
; 87(28): 1981-3, 2007 Jul 24.
Article
em Zh
| MEDLINE
| ID: mdl-17923039
ABSTRACT
OBJECTIVE:
To quantify peripheral blood mononuclear cell JAK3 mRNA levels after allogeneic haematopoietic stem cell (allo-HSCT) transplantation, and to explore its relationship with graft vs host disease (GVHD).METHODS:
Serial monitoring of JAK3 mRNA levels by fluorescent quantitative reverse transcriptase polymerase chain reaction (FQ-RT-PCR) technique was performed on 26 cases (83 samples) after allo-HSCT.RESULTS:
The mean JAK3/ABL expression levels was 8.71 in 14 patients without GVHD; the JAK3/ABL expression level was 31.94 in one patient with acute GVHD (aGVHD); the mean JAK3/ABL expression levels was 19.23 in 11 patients with chronic GVHD (cGVHD), and the cGVHD was diagnosed at the mean time of six months (3 - 12 months). The JAK3/ABL expression levels did not change in 4 patients one month after allo-HSCT, however, the levels increased again when GVHD were diagnosed in these 4 patients, and the JAK3/ABL expression levels decreased again when GVHD was remitted.CONCLUSION:
The JAK3 expression level related to the remission and relapse in patients with GVHD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Janus Quinase 3
/
Doença Enxerto-Hospedeiro
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article