Phosphorothioation of DNA in bacteria by dnd genes.
Nat Chem Biol
; 3(11): 709-10, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-17934475
ABSTRACT
Modifications of the canonical structures of DNA and RNA play critical roles in cell physiology, DNA replication, transcription and translation in all organisms. We now report that bacterial dnd gene clusters incorporate sulfur into the DNA backbone as a sequence-selective, stereospecific phosphorothioate modification. To our knowledge, unlike any other DNA or RNA modification systems, DNA phosphorothioation by dnd gene clusters is the first physiological modification described on the DNA backbone.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
/
DNA Bacteriano
/
Genes Bacterianos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article