A diastereoselective intermolecular heck reaction of 1,3-dioxepins.
Org Lett
; 9(24): 5099-102, 2007 Nov 22.
Article
em En
| MEDLINE
| ID: mdl-17958436
ABSTRACT
A highly diastereoselective intermolecular Heck reaction of 1,3-dioxepins is reported. Substitution at both the 2- and 4-positions of the dioxepin directs the Pd coordination and subsequent olefin insertion to provide the trans-disubstituted adduct in good yield and high diastereoselectivity. Chemoselective Heck reaction occurs at the dioxepin alkene in the presence of other olefinic functional groups. A labeling study has been conducted which suggests that the reaction is under kinetic control.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxepinas
/
Éteres Cíclicos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article