Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.
Bioorg Med Chem Lett
; 17(24): 6811-5, 2007 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-17964783
ABSTRACT
A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [(3)H]-LY354740 to rat mGluR2 with low nanomolar affinity and consistent functional effect at both mGluR2 and mGluR3.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azepinas
/
Receptores de Glutamato Metabotrópico
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article