The cell mediated and humoral immune response to vaccination with acellular and whole cell pertussis vaccine in adult humans.
FEMS Microbiol Immunol
; 3(5): 279-87, 1991 Oct.
Article
em En
| MEDLINE
| ID: mdl-1797049
ABSTRACT
The cell mediated immune response (CMI) against pertussis antigens following vaccination with the traditional Danish whole cell pertussis vaccine (WC-P) and the Japanese acellular pertussis vaccine (A-PV) JNIH-3 was studied in four adult human volunteers. Vaccination with the A-PV induced an in vitro proliferative response of peripheral blood lymphocytes to pertussis toxin (PT) subunits S2-S4, S3-S4 and S5 and the filamentous hemagglutinin (FHA), and a better serological response to native PT, detoxified PT (dPT) and FHA than the WC-PV. The induced CMI and serological response were followed over a period of 17 weeks, and were not seen to decline during this period. Further, an in vitro proliferative response to Bordetella pertussis agglutinogen 2 and 3 were demonstrated using lymphocytes from recently and not-so-recently pertussis-vaccinated adults.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Virulência de Bordetella
/
Vacina contra Coqueluche
/
Adesinas Bacterianas
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Imunidade Celular
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Formação de Anticorpos
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article