Verification of a designed intramolecular hydrogen bond in a drug scaffold by nuclear magnetic resonance spectroscopy.
J Med Chem
; 50(24): 5875-7, 2007 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-17975906
ABSTRACT
2D 1H-15N HMBC NMR acquired at natural abundance and DMSO titration monitored by 1D 1H NMR verified the existence of an intramolecular hydrogen bond that was designed to mimic the pyrimidinone ring of a class of kinase inhibitors. A scalar coupling across the hydrogen bond was detected in organic and aqueous solvent, suggesting a simple and general approach for testing the propensity of intramolecular hydrogen bonds to stabilize pseudo-rings in drug scaffolds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Piridonas
/
Pirimidinas
/
Desenho de Fármacos
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article