A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women.
BJOG
; 114(12): 1510-5, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-17995495
ABSTRACT
OBJECTIVE:
To study the prophylactic use of levonorgestrel intrauterine system (LNG-IUS) in the prevention of endometrial pathology in women having breast cancer treated with tamoxifen.DESIGN:
Randomised controlled trial.SETTING:
A tertiary teaching hospital. POPULATION One hundred and thirteen women (66 premenopausal/47 postmenopausal) who required adjuvant tamoxifen for breast cancer after the completion of postoperative radiotherapy and chemotherapy.METHODS:
Women were randomised to treatment group (prophylactic LNG-IUS insertion before the commencement of tamoxifen) or control group. Uterine cavity was examined by outpatient hysteroscopy and endometrial biopsy before and at 12 months after commencement of tamoxifen. MAIN OUTCOMEMEASURES:
De novo endometrial pathology at 1 year of tamoxifen.RESULTS:
Women in the treatment group had a much lower incidence of endometrial polyp (1.8 versus 15.5%, P= 0.017) (relative risk 0.12; 95% CI 0.02-0.91) at 12 months. There was no significant difference in the incidence of submucosal fibroid between the two groups (1.8 versus 3.4%, P= 1.0). LNG-IUS was retained in 95% women in the treatment group at 1 year.CONCLUSION:
LNG-IUS reduces the occurrence of de novo endometrial polyp in women treated with tamoxifen for breast cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tamoxifeno
/
Doenças Uterinas
/
Neoplasias da Mama
/
Levanogestrel
/
Antineoplásicos Hormonais
/
Dispositivos Intrauterinos Medicados
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article