Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir.
Nucleosides Nucleotides Nucleic Acids
; 26(8-9): 953-7, 2007.
Article
em En
| MEDLINE
| ID: mdl-18058516
Homo- and heterodimers of nucleoside/nucleotide analogues as reverse transcriptase inhibitors are effective on HIV-1-infected human monocyte-derived macrophages (M/M) compared to the single drugs or their combination. Since the combined treatment of lamivudine (3TC) and tenofovir ((R)PMPA) has an antiretroviral efficacy and a synergic effect respect to separate drugs, the heterodinucleotide 3TCpPMPA was synthesized. A single administration of the dimer as free drug or 3TCpPMPA-loaded RBC selectively targeted to M/M was able to almost completely protect macrophages from "de novo" infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenina
/
Lamivudina
/
Fármacos Anti-HIV
/
Organofosfonatos
Limite:
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article