Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.
Bioorg Med Chem Lett
; 18(2): 479-84, 2008 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-18068977
ABSTRACT
Dipeptidyl peptidase-IV (DPP-IV) is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). In this report, we show that the hypolipidemic agent atorvastatin is a competitive inhibitor of porcine DPP-IV in vitro, with K(i)=57.8+/-2.3 microM. These results may have implications in the development of novel DPP-IV inhibitors based on the use of atorvastatin as a lead compound for the treatment of type 2 diabetes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Pirróis
/
Inibidores da Dipeptidil Peptidase IV
/
Ácidos Heptanoicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article