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Human bocavirus commonly involved in multiple viral airway infections.
Christensen, Andreas; Nordbø, Svein Arne; Krokstad, Sidsel; Rognlien, Anne Gro Wesenberg; Døllner, Henrik.
Afiliação
  • Christensen A; Department of Medical Microbiology, St. Olavs Hospital, Trondheim University Hospital, Norway. andreas.christensen@stolav.no <andreas.christensen@stolav.no>
J Clin Virol ; 41(1): 34-7, 2008 Jan.
Article em En | MEDLINE | ID: mdl-18069054
BACKGROUND: Human bocavirus (HBoV) was recently discovered in children with acute respiratory tract infections. We have included a PCR for HBoV in a study on airway infections in children. OBJECTIVES: To study the occurrence of HBoV in Norwegian children, and to evaluate the results of a semiquantitative PCR. STUDY DESIGN: During a 4-month period in the winter season 2006/2007 we collected nasopharyngeal aspirations from children who were admitted to the Department of Pediatrics. All samples were examined for 17 agents with real-time PCR. RESULTS: HBoV was detected in 45 of 376 samples (12%). The occurrence of HBoV was stable during the study period. Multiple viral infections were present in 78% of the samples (42% double, 20% triple and 16% quadruple infections). RS-virus, enterovirus and human metapneumovirus were the most frequently codetected agents. In samples with a high load for HBoV, significantly fewer multiple infections were found than in the other samples. Eighty-eight percent of the 25 patients with HBoV recorded as either the only or the dominating virus, and 50% of the other patients, had lower respiratory tract infection. The difference was statistically significant. CONCLUSIONS: HBoV was frequently detected in nasopharyngeal aspirates from children with airway infections in Norway. Multiple viral infections were common among the HBoV-infected patients. Semiquantitative PCR results may be useful for interpretation of clinical relevance.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Infecções por Parvoviridae / Bocavirus Limite: Female / Humans / Infant / Male País/Região como assunto: Europa Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Infecções por Parvoviridae / Bocavirus Limite: Female / Humans / Infant / Male País/Região como assunto: Europa Idioma: En Ano de publicação: 2008 Tipo de documento: Article