Cholesterol shows preference for the interior of polyunsaturated lipid membranes.
J Am Chem Soc
; 130(1): 10-1, 2008 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-18076174
ABSTRACT
Recent neutron scattering experiments showed a striking manifestation of the aversion between polyunsaturated fatty acid (PUFA)-containing lipids and cholesterol. Selectively deuterated cholesterol/ 1,2-diarachidonylphosphatidylcholine (DAPC) samples revealed that the hydroxyl of the sterol resides at the center of the bilayer. Here we use a recently parametrized coarse grain simulation model to shed light on these puzzling experimental observations. Using a simulation setup in close correspondence to the experimental conditions, we reproduce the experimental neutron scattering profiles to a large extent. The simulations allow us to analyze the behavior of cholesterol in detail; we show that the interaction of cholesterol with the PUFA chains of DAPC leads to a fast flip-flop rate for the sterol and an increased preference of the sterol for the unusual location embedded between the monolayer leaflets.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colesterol
/
Ácidos Graxos Insaturados
/
Bicamadas Lipídicas
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article