Facile synthesis of a "ready to use" precursor of porphobilinogen and its amino Acid derivatives.
J Org Chem
; 73(2): 764-7, 2008 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-18081349
ABSTRACT
A practical synthesis of porphobilinogen based on the biosynthetic mechanism is described. The crossed Mukayiama aldol reaction is the key step creating the central carbon-carbon bond between the two protected forms of 5-aminolevulinic acids. The optimized sequence gives a crystalline, storable precursor, which can be transformed in high yield into porphobilinogen and bioconjugates thereof. The enzymatic hydrolysis of the precursor produces porphobilinogen in quantitative yield.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfobilinogênio
/
Aminoácidos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article