Hepatobiliary elimination of bendamustin (Cytostasan) in rats.
Pharmazie
; 46(11): 810-1, 1991 Nov.
Article
em En
| MEDLINE
| ID: mdl-1811234
Biliary excretion of bendamustin (Cytostasan, 5-[bis(2-chloroethyl)amino]-i-methylbenzimidazole-2-butyric acid; 1) and its metabolites was studied in rats after i.v. administration of 14C-1. The most significant finding was the rapid excretion of 1 related radioactivity in the bile occurring shortly after injection. While radioactivity eliminated by bile within 2 h was 41.8%, in the course of subsequent 22 h it amounted only to 3.2%. Bile samples analyzed by TLC indicated that the total amount of radioactivity was excreted in the form of conjugates and two hydroxy metabolites. A significant amount of radioactivity was excreted in urine. The diversion of bile by cannulation of the bile duct led to a significant decrease of elimination by feces.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bile
/
Fígado
/
Compostos de Mostarda Nitrogenada
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article