[Effect of insulin on the activity of bone alkaline phosphatase in culture]. / L'effetto dell'insulina sull'attività di fosfatasi alcalina dell'osso in coltura.
Minerva Endocrinol
; 16(4): 187-91, 1991.
Article
em It
| MEDLINE
| ID: mdl-1815119
ABSTRACT
Diabetes and osteoporosis are linked. The question remains, however, as to whether insulin has any direct effect on bone formation. To test this hypothesis we have measured, as a marker of osteoblast activity, alkaline phosphatase (ALP) released by rat limb intact bones incubated in the presence and in the absence of physiological concentration of insulin. The results indicate that insulin significantly (p less than 0.012) increases ALP by a mean value of 48% (from 5.4% to 215%) over matched controls. We conclude that insulin has a direct stimulatory effect on osteoblast activity, and that in the absence of this effect, as in diabetes, bone loss might occur.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Fosfatase Alcalina
/
Insulina
Limite:
Animals
Idioma:
It
Ano de publicação:
1991
Tipo de documento:
Article