Excessive dopamine neuron loss in progressive supranuclear palsy.
Mov Disord
; 23(4): 607-10, 2008 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-18163454
ABSTRACT
Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paralisia Supranuclear Progressiva
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Substância Negra
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Dopamina
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Degeneração Neural
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Neurônios
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article