The catalytic asymmetric total synthesis of elatol.
J Am Chem Soc
; 130(3): 810-1, 2008 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-18163634
ABSTRACT
Described in this report is the first total synthesis of elatol, a halogenated sesquiterpene in the chamigrene natural product family. The key disconnections in our synthetic approach include an enantioselective decarboxylative allylation to form the all-carbon quaternary stereocenter and a ring-closing olefin metathesis to concomitantly form the spirocyclic core as well as the fully substituted chlorinated olefin. This strategy represents a general platform for accessing the chamigrene natural product family, as demonstrated by the synthesis of (+)-laurencenone B as an intermediate in our route.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Compostos de Espiro
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article